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Clostridium Difficile
Introduction
  • Clostridium difficile, or C.Diff, is a bacteria that causes severe antibiotic-associated diarrhea. This is because its great at colonising the gut after normal bowel flora are disrupted by broad-spectum antibiotics. It can then produce inflammatory toxins in the large bowel, resulting in foul smelling watery stools.

The management or step-up therapy for C.diff is

vancomycin, fidaxomicin, then transplant stools-in.

 

I’ve also got a way to remember the definition of fulminant colitis. This is when there is shock, the bowels stop or get bigger than Bangkok. This highlights that shock, an ileus or the development of a massive megacolon, are the key features to look out for. To manage this, you might need a chop in surgery.

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